This "sumptuous, Regency-style limestone house" was built in the early 1930s, its 55 rooms occupied by Mr. Loew, his wife, and 16 servants. Along with another massive residence erected on this block of East 93rd Street in the early years of the Great Depression, it was one of the last grand mansions constructed in Manhattan. In more recent years, it was home to the Smithers Alcoholism Treatment and Training Center before being purchased in 1999 by the private all-girls Spence School.